Common Questions and Answers about Omeprazole and weight loss nexium From what I've read, the affect of Prilosec is pretty small, and an increase in exercise, sun exposure, weight loss , and a good vitamin can offset the effects of the drug. Unexplained weight loss Your risk for broken bones in your hip, spine, or wrist may increase while taking omeprazole. The risk increases if you are older than 50, take high doses of omeprazole, or take it for more than a year. Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Omeprazole is used to treat symptoms of gastroesophageal reflux disease and other conditions caused by excess stomach acid. Omeprazole is a medication called a proton pump inhibitor. It is most commonly used for moderate symptoms of gastric reflux. Unexplained weight loss has many causes, medical and nonmedical. Often, a combination of things results in a general decline in your health and a related weight loss. Sometimes a specific cause isn't found. WebMD Symptom Checker helps you find the most common symptom combinations and medical conditions related to Weight loss (unintentional). Uses. Omeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. Sudden or unusual weight gain is a highly uncommon, but dangerous side effect of omeprazole. If you take a form of omeprazole and experience this symptom, seek medical attention immediately. If not, get back to your doctor and explain that you a re worried sick and need answers with regard to the weight loss. If the doctor thought your weight loss was anything sinister then he or she.